For USB 2.0 facility, on the console:

# VBoxManage extpack install  /opt/VirtualBox/ExtensionPacks/Oracle_VM_VirtualBox_Extension_Pack-*

To remove USB 2.0 Oracle extensions before an update:

# VBoxManage list extpacks
# VBoxManage extpack uninstall "Oracle VM VirtualBox Extension Pack"
# VBoxManage extpack cleanup

Then you can install the new version as above. No need to reboot.

Enjoy it :)